二氢丹参酮I

二氢丹参酮I
	IUPAC名; 4,17β-Dimethyl-15-oxagona-1,3,5,7,9,13-hexaene-11,12-dione
	系统名; (1R)-1,6-Dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione
别名	15,16-dihydrotanshinone I, phenanthro[1,2-b]furan-10,11-dione, 1,2-dihydro-1,6-dimethyl-
识别
缩写	DI
CAS号	87205-99-0
PubChem	11425923
ChemSpider	9600799
SMILES	O=C2c3c(C=1OCC(C=1C2=O)C)ccc4c(cccc34)C;
InChI	1/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3;
性质
化学式	C18H14O3
摩尔质量	278.3 g·mol−1
外观	Red powder
密度	1.32 g/cm3
沸点	479.2 °C（752 K）
溶解性（水）	12.9 mg/L (est.)
溶解性（ethanol）	1 mg/mL, clear orange to red
log P	log Kow = 3.93 (est)
蒸氣壓	3.41x10−9 mmHg
危险性
	GHS危险性符号;
GHS提示词	警告
H-术语	H302, H400
P-术语	P264, P270, P273, P301+312, P330, P391, P501
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

二氢丹参酮I（英語：Dihydrotanshinone I；简称DI）是从丹参中提取的一种天然化合物。它属于一类亲脂性松香烷二萜类化合物，^[2]据报道对多种肿瘤细胞具有细胞毒性，^[3]同时在体外具有抗病毒作用。^[4]自从它们被首次发现以来，已经从丹参中分离出了40多种相关化合物和50多种亲水性化合物。^[2]

参考资料[编辑]

^ Dihydrotanshinone I. PubChem. PubChem. [31 August 2015].
^ ^2.0 ^2.1 HSDB: DIHYDROTANSHINONE I. NIH. [1 September 2015].
^ Bian W, Chen F, Bai L, Zhang P, Qin W. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochimica et Biophysica Sinica. January 2008, 40 (1): 1–6. PMID 18180848. doi:10.1111/j.1745-7270.2008.00370.x.
^ Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, Drury LS, Milligan JC, Zeisner TU, Zeng J, Weissmann F, Canal B, Bineva-Todd G, Howell M, O'Reilly N, Beale R, Kulathu Y, Labib K, Diffley JF. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical Journal. July 2021, 478 (13): 2517–2531. PMC 8286840 . PMID 34198325. doi:10.1042/BCJ20210244.

这是一篇关于有机化合物的小作品。你可以通过编辑或修订扩充其内容。

[PC-1] Dihydrotanshinone I. PubChem. PubChem. [31 August 2015].

[NIH-2] 2.0 ^2.1 HSDB: DIHYDROTANSHINONE I. NIH. [1 September 2015].

[ABBS-3] Bian W, Chen F, Bai L, Zhang P, Qin W. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochimica et Biophysica Sinica. January 2008, 40 (1): 1–6. PMID 18180848. doi:10.1111/j.1745-7270.2008.00370.x.

[pmid34198325-4] Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, Drury LS, Milligan JC, Zeisner TU, Zeng J, Weissmann F, Canal B, Bineva-Todd G, Howell M, O'Reilly N, Beale R, Kulathu Y, Labib K, Diffley JF. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical Journal. July 2021, 478 (13): 2517–2531. PMC 8286840 . PMID 34198325. doi:10.1042/BCJ20210244.

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