氟胺酮

**氟胺酮**
法律規範狀態
法律規範	加：Schedule I; 德：NpSG; 英：Class B; Illegal in Italy, Japan, Latvia, Singapore, Sweden and Switzerland;
识别信息
	IUPAC命名法 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone; ;
CAS号	111982-50-4
PubChem CID	13771618;
ChemSpider	43515873;
UNII	D57WIH0RIT;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID001018395 ;
化学信息
化学式	C13H16FNO
摩尔质量	221.28 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CNC1(CCCCC1=O)c2ccccc2F;
	InChI InChI=1S/C13H16FNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3; Key:PHFAGYYTDLITTB-UHFFFAOYSA-N;

氟胺酮（2-氟脱氯氯胺酮、2-FDCK）是一种解离麻醉药，^[1]和氯胺酮结构相似，在一些国家作为狡诈家药物出售。^[2]^[3]^[4]

管制信息[编辑]

氟胺酮在意大利、^[5]日本、^[6]拉脱维亚、^[7]新加坡、^[8]瑞典^[9]、瑞士^[10]和中国^[11]是非法物质；在加拿大、^[12]比利时^[13]和英国^[14]被全面禁止。

参考文献[编辑]

^ Moghimi A, Rahmani S, Zare R, Sadeghzadeh M. Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative. Synthetic Communications. 2014-07-18, 44 (14): 2021–2028 [2023-02-21]. S2CID 98475552. doi:10.1080/00397911.2014.885053. （原始内容存档于2023-02-21）（英语）.
^ Davidsen AB, Mardal M, Holm NB, Andreasen AK, Johansen SS, Noble C, et al. Ketamine analogues: Comparative toxicokinetic in vitro-in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples. Journal of Pharmaceutical and Biomedical Analysis. February 2020, 180: 113049. PMID 31881397. S2CID 209499229. doi:10.1016/j.jpba.2019.113049.
^ Wang PF, Neiner A, Lane TR, Zorn KM, Ekins S, Kharasch ED. Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches. Molecular Pharmaceutics. February 2019, 16 (2): 898–906. PMC 9121441 . PMID 30589555. doi:10.1021/acs.molpharmaceut.8b01214.
^ Tang MH, Li TC, Lai CK, Chong YK, Ching CK, Mak TW. Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues. Forensic Science International. July 2020, 312: 110327. PMID 32460225. S2CID 218954528. doi:10.1016/j.forsciint.2020.110327.
^ Article 1. Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni ed integrazioni. Inserimento nella tabella I e nella tabella IV di nuove sostanze psicoattive. 13 March 2020 [2023-02-21]. （原始内容存档于2022-11-16）（Italian）.
^ "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare
^ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem. Latvijas Republikas tiesību akti. [2023-02-21]. （原始内容存档于2023-02-21）（Latvian）.
^ Misuse of Drugs Act – Singapore Statutes Online. sso.agc.gov.sg. [2023-02-21]. （原始内容存档于2021-04-17）.
^ Förordning (1999:58) om förbud mot vissa hälsofarliga varor Svensk författningssamling 1999:1999:58 t.o.m. SFS 2019:631 – Riksdagen. Riksdagsförvaltningen. www.riksdagen.se. [2023-02-21]. （原始内容存档于2023-02-21）（Swedish）.
^ Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien. Der Bundesrat. [2023-02-21]. （原始内容存档于2023-04-27）（German）.
^ 关于将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告 (PDF). 中华人民共和国公安部. 2021-05-12 （中文（中国大陆））.
^ Controlled Drugs and Substances Act (S.C. 1996, c. 19). March 18, 2021 [2023-02-21]. （原始内容存档于2022-04-08）.
^ de Schutter A, Evenepoel T, Schrooten J. Dossier Nieuwe Psychoactieve Stoffen. Brussel: VAD. 2019 [2023-02-21]. （原始内容存档于2023-05-25）.
^ Misuse of Drugs Act 1971. [7 March 2021]. （原始内容存档于2023-03-09）.

[Moghimi_2014-1] Moghimi A, Rahmani S, Zare R, Sadeghzadeh M. Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative. Synthetic Communications. 2014-07-18, 44 (14): 2021–2028 [2023-02-21]. S2CID 98475552. doi:10.1080/00397911.2014.885053. （原始内容存档于2023-02-21）（英语）.

[Davidsen_2020-2] Davidsen AB, Mardal M, Holm NB, Andreasen AK, Johansen SS, Noble C, et al. Ketamine analogues: Comparative toxicokinetic in vitro-in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples. Journal of Pharmaceutical and Biomedical Analysis. February 2020, 180: 113049. PMID 31881397. S2CID 209499229. doi:10.1016/j.jpba.2019.113049.

[Wang_2019-3] Wang PF, Neiner A, Lane TR, Zorn KM, Ekins S, Kharasch ED. Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches. Molecular Pharmaceutics. February 2019, 16 (2): 898–906. PMC 9121441 . PMID 30589555. doi:10.1021/acs.molpharmaceut.8b01214.

[Tang_2020-4] Tang MH, Li TC, Lai CK, Chong YK, Ching CK, Mak TW. Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues. Forensic Science International. July 2020, 312: 110327. PMID 32460225. S2CID 218954528. doi:10.1016/j.forsciint.2020.110327.

[5] Article 1. Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni ed integrazioni. Inserimento nella tabella I e nella tabella IV di nuove sostanze psicoattive. 13 March 2020 [2023-02-21]. （原始内容存档于2022-11-16）（Italian）.

[6] "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare

[7] Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem. Latvijas Republikas tiesību akti. [2023-02-21]. （原始内容存档于2023-02-21）（Latvian）.

[8] Misuse of Drugs Act – Singapore Statutes Online. sso.agc.gov.sg. [2023-02-21]. （原始内容存档于2021-04-17）.

[9] Förordning (1999:58) om förbud mot vissa hälsofarliga varor Svensk författningssamling 1999:1999:58 t.o.m. SFS 2019:631 – Riksdagen. Riksdagsförvaltningen. www.riksdagen.se. [2023-02-21]. （原始内容存档于2023-02-21）（Swedish）.

[10] Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien. Der Bundesrat. [2023-02-21]. （原始内容存档于2023-04-27）（German）.

[11] 关于将合成大麻素类物质和氟胺酮等18种物质列入《非药用类麻醉药品和精神药品管制品种增补目录》的公告 (PDF). 中华人民共和国公安部. 2021-05-12 （中文（中国大陆））.

[12] Controlled Drugs and Substances Act (S.C. 1996, c. 19). March 18, 2021 [2023-02-21]. （原始内容存档于2022-04-08）.

[13] Schutter A, Evenepoel T, Schrooten J. Dossier Nieuwe Psychoactieve Stoffen. Brussel: VAD. 2019 [2023-02-21]. （原始内容存档于2023-05-25）.

[14] Misuse of Drugs Act 1971. [7 March 2021]. （原始内容存档于2023-03-09）.

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