阿莫待奎

**阿莫待奎**
臨床資料
商品名（英语：Drug nomenclature）	Amdaquine, Amobin, others
AHFS/Drugs.com	国际药品名称
ATC碼	P01BA06 (WHO) ;
识别信息
	IUPAC命名法 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol; ;
CAS号	86-42-0
PubChem CID	2165;
DrugBank	DB00613 ;
ChemSpider	2080 ;
UNII	220236ED28;
KEGG	D02922 ;
ChEBI	CHEBI:2674 ;
ChEMBL	ChEMBL682 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID2022597 ;
ECHA InfoCard	100.001.518
化学信息
化学式	C20H22ClN3O
摩尔质量	355.87 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Clc1cc2nccc(c2cc1)Nc3cc(c(O)cc3)CN(CC)CC;
	InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) ; Key:OVCDSSHSILBFBN-UHFFFAOYSA-N ;

阿莫待奎（英語：Amodiaquine，簡稱為 ADQ）是治療瘧疾的藥物，也用來治療沒有併發症的惡性瘧原蟲瘧疾（英語：Plasmodium falciparum malaria）^[2]^[3]。為降低其抗藥性，建議和青蒿琥酯一起給藥^[2]。此藥物偶爾會出現嚴重的副作用，因此一般不建議用此藥物來預防瘧疾^[2]。

阿莫待奎是類似氯喹的4-氨基喹啉化合物^[2]，副作用也和氯喹類似，屬於輕微或中等.^[3]，罕見的副作用為肝病及血球數目降低（英语：low blood cell levels）等^[2]，若在嚴重頭痛時服用，可能會有視力問題、癲癇發作、心搏停止等症狀^[2]。截至2007年，雖尚未徹底研究懷孕使用的安全性，現有資訊來看應該是安全的^[4]。

1948年，阿莫待奎問世^[5]，名列世界衛生組織基本藥物標準清單，認可為醫療系統中最安全有效的必需藥物之一^[6]。截至2014年，一劑阿莫待奎僅需約0.01美元^[7]。雖然此藥目前在美國無法取得^[8]，但在非洲廣泛流通^[2]^[9]。

附註[编辑]

^ Amodiaquine. drugs.com. [27 November 2016]. （原始内容存档于27 November 2016）.
^ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Nair, A; Abrahamsson, B; Barends, DM; Groot, DW; Kopp, S; Polli, JE; Shah, VP; Dressman, JB. Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride. Journal of Pharmaceutical Sciences. December 2012, 101 (12): 4390–401. PMID 22949374. doi:10.1002/jps.23312.
^ ^3.0 ^3.1 Olliaro, P; Mussano, P. Amodiaquine for treating malaria. The Cochrane Database of Systematic Reviews. 2003, (2): CD000016. PMID 12804382. doi:10.1002/14651858.CD000016.
^ Tagbor, HK; Chandramohan, D; Greenwood, B. The safety of amodiaquine use in pregnant women. Expert Opinion on Drug Safety. November 2007, 6 (6): 631–5. PMID 17967151. doi:10.1517/14740338.6.6.631.
^ Profiles of Drug Substances, Excipients and Related Methodology. Academic Press. 1992: 45. ISBN 9780080861166. （原始内容存档于2017-09-08）（英语）.
^ WHO Model List of Essential Medicines (19th List) (PDF). World Health Organization. April 2015 [8 December 2016]. （原始内容 (PDF)存档于13 December 2016）.
^ Amodiaquine. International Drug Price Indicator Guide. [4 December 2015]. （原始内容存档于2019-03-29）.
^ Amodiaquine. Livertox. [27 November 2016]. （原始内容存档于27 November 2016）.
^ Centers for Disease Control, (CDC). Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum.. MMWR. Morbidity and Mortality Weekly Report. 12 April 1985, 34 (14): 185–90, 195. PMID 3156271.

[1] Amodiaquine. drugs.com. [27 November 2016]. （原始内容存档于27 November 2016）.

[Na2012-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Nair, A; Abrahamsson, B; Barends, DM; Groot, DW; Kopp, S; Polli, JE; Shah, VP; Dressman, JB. Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride. Journal of Pharmaceutical Sciences. December 2012, 101 (12): 4390–401. PMID 22949374. doi:10.1002/jps.23312.

[Co2003-3] 3.0 ^3.1 Olliaro, P; Mussano, P. Amodiaquine for treating malaria. The Cochrane Database of Systematic Reviews. 2003, (2): CD000016. PMID 12804382. doi:10.1002/14651858.CD000016.

[4] Tagbor, HK; Chandramohan, D; Greenwood, B. The safety of amodiaquine use in pregnant women. Expert Opinion on Drug Safety. November 2007, 6 (6): 631–5. PMID 17967151. doi:10.1517/14740338.6.6.631.

[5] Profiles of Drug Substances, Excipients and Related Methodology. Academic Press. 1992: 45. ISBN 9780080861166. （原始内容存档于2017-09-08）（英语）.

[WHO19th-6] WHO Model List of Essential Medicines (19th List) (PDF). World Health Organization. April 2015 [8 December 2016]. （原始内容 (PDF)存档于13 December 2016）.

[7] Amodiaquine. International Drug Price Indicator Guide. [4 December 2015]. （原始内容存档于2019-03-29）.

[8] Amodiaquine. Livertox. [27 November 2016]. （原始内容存档于27 November 2016）.

[CDC1985-9] Centers for Disease Control, (CDC). Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum.. MMWR. Morbidity and Mortality Weekly Report. 12 April 1985, 34 (14): 185–90, 195. PMID 3156271.

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