PANC-1

PANC-1是人類胰腺癌細胞系^[1]，最初是分離一名56歲男性胰腺癌患者。PANC-1細胞可以遠端轉移，但細胞分化的能力差^[2]，需要52個小時才能增加一倍的種群。PANC-1細胞的模態染色體數為63，包括3個獨特的標記染色體（英语：Marker chromosome）和1個小環狀染色體，並且顯示出慢遷移性類型的G6PD^[1]。目前已知PANC-1細胞具有上皮形態及會粘附在細胞培養瓶中。只要適當地提高細胞的溫度，細胞就會在培養物中再度生長。PANC-1細胞有結塊的趨勢，而進行胰蛋白酶的處理則可以避免這種現象^[3]。PANC-1細胞已被用於研究角蛋白重組在癌細胞遷移過程中的作用，以及鈣介導的肌動蛋白在響應生理變化時的重置^[2]。

參考資料[编辑]

^ ^1.0 ^1.1 Lieber, M; Mazzetta, J; Nelson-Rees, W; Kaplan, M; Todaro, G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.. International journal of cancer. 1975-05-15, 15 (5): 741–7 [2020-01-12]. PMID 1140870. doi:10.1002/ijc.2910150505. （原始内容存档于2020-01-12）.
^ ^2.0 ^2.1 Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2020-01-12]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963. （原始内容存档于2020-01-12）.
^ Thompson Evonne. Cell Growth Protocol for PANC-1 cell line (PDF). Myers Laboratory. 2009-07-22 [2020-01-12]. （原始内容存档 (PDF)于2017-09-18）（英语）.

外部連結[编辑]

Cellosaurus entry for PANC-1（页面存档备份，存于互联网档案馆）

[a-1] 1.0 ^1.1 Lieber, M; Mazzetta, J; Nelson-Rees, W; Kaplan, M; Todaro, G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.. International journal of cancer. 1975-05-15, 15 (5): 741–7 [2020-01-12]. PMID 1140870. doi:10.1002/ijc.2910150505. （原始内容存档于2020-01-12）.

[b-2] 2.0 ^2.1 Deer, EL; González-Hernández, J; Coursen, JD; Shea, JE; Ngatia, J; Scaife, CL; Firpo, MA; Mulvihill, SJ. Phenotype and genotype of pancreatic cancer cell lines.. Pancreas. 2010-05, 39 (4): 425–35 [2020-01-12]. PMID 20418756. doi:10.1097/MPA.0b013e3181c15963. （原始内容存档于2020-01-12）.

[3] Thompson Evonne. Cell Growth Protocol for PANC-1 cell line (PDF). Myers Laboratory. 2009-07-22 [2020-01-12]. （原始内容存档 (PDF)于2017-09-18）（英语）.

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