FTO基因

肥胖基因
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3LFM、4IDZ、4IE0、4IE4、4IE5、4IE6、4IE7、4CXW、4CXX、4CXY、4QHO、4QKN、4ZS3、4ZS2
识别号
别名	FTO；, ALKBH9, GDFD, BMIQ14, fat mass and obesity associated, alpha-ketoglutarate dependent dioxygenase
外部ID	OMIM：610966 MGI：1347093 HomoloGene：8053 GeneCards：FTO
相关疾病
	2型糖尿病、肥胖症、morbid obesity、黑色素瘤、退化性关节炎、代谢疾病、慢性阻塞性肺病、lethal polymalformative syndrome, Boissel type
基因位置（人类）
染色体	16号染色体
终止	54,158,512 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	92,395,067 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• oxidative DNA demethylase activity; • dioxygenase activity; • 金属离子结合; • DNA-N1-methyladenine dioxygenase activity; • oxidoreductase activity; • ferrous iron binding; • mRNA N6-methyladenosine dioxygenase activity; • oxidative RNA demethylase activity;
细胞组分	• nuclear speck; • 细胞核; • 核质;
生物学过程	• regulation of multicellular organism growth; • regulation of respiratory system process; • regulation of white fat cell proliferation; • cellular response to DNA damage stimulus; • oxidative demethylation; • oxidative single-stranded RNA demethylation; • regulation of lipid storage; • RNA repair; • adipose tissue development; • DNA去甲基化; • regulation of brown fat cell differentiation; • temperature homeostasis; • oxidative single-stranded DNA demethylation; • DNA修复; • DNA dealkylation involved in DNA repair;
	Sources:Amigo / QuickGO
直系同源
	79068
	26383
	ENSG00000140718
	ENSMUSG00000055932
	Q9C0B1
	Q8BGW1
	NM_001080432
	NM_011936
NP_001073901; NP_001350820; NP_001350823; NP_001350825; NP_001350826;
	NP_001350827; NP_001350828; NP_001350829; NP_001350830; NP_001350832; NP_001350834; NP_001350917
	NP_036066
	维基数据
查看/编辑人类	查看/编辑小鼠

FTO基因全称脂肪和肥胖相关基因（Fat mass and obesity-associated），在人类基因组中位于16号染色体，此基因编码的FTO蛋白属AlkB家族（英语：AlkB）（即与细菌的AlkB蛋白同源^[6]^[7]），为α-酮戊二酸依赖性羟化酶（英语：alpha-ketoglutarate-dependent hydroxylase）^[6]。此基因可能与肥胖症有关^[8]^[9]。2011年何川实验室发现FTO蛋白可将mRNA上的N6-甲基腺苷（m⁶A）去甲基化成腺苷（A），为第一个被发现的mRNA去甲基酶^[10]^[11]。

参考文献[编辑]

^ 與肥胖基因相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000140718 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055932 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^6.0 ^6.1 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. November 2007, 318 (5855): 1469–72. Bibcode:2007Sci...318.1469G. PMC 2668859 . PMID 17991826. doi:10.1126/science.1151710.
^ Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry. November 2007, 8: 23. PMC 2241624 . PMID 17996046. doi:10.1186/1471-2091-8-23.
^ Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. January 2014, 10 (1): 51–61. PMC 4188449 . PMID 24247219. doi:10.1038/nrendo.2013.227.
^ Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine. September 2015, 373 (10): 895–907. PMC 4959911 . PMID 26287746. doi:10.1056/NEJMoa1502214.
^ Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology. October 2011, 7 (12): 885–7. PMC 3218240 . PMID 22002720. doi:10.1038/nchembio.687.
^ Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. June 2012, 149 (7): 1635–46. PMC 3383396 . PMID 22608085. doi:10.1016/j.cell.2012.05.003.

[1] 與肥胖基因相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000140718 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000055932 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Gerken_2007-6] 6.0 ^6.1 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. November 2007, 318 (5855): 1469–72. Bibcode:2007Sci...318.1469G. PMC 2668859 . PMID 17991826. doi:10.1126/science.1151710.

[Sanchez-Pulido_2007-7] Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry. November 2007, 8: 23. PMC 2241624 . PMID 17996046. doi:10.1186/1471-2091-8-23.

[Loos_2014-8] Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. January 2014, 10 (1): 51–61. PMC 4188449 . PMID 24247219. doi:10.1038/nrendo.2013.227.

[9] Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine. September 2015, 373 (10): 895–907. PMC 4959911 . PMID 26287746. doi:10.1056/NEJMoa1502214.

[Jia_2011-10] Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology. October 2011, 7 (12): 885–7. PMC 3218240 . PMID 22002720. doi:10.1038/nchembio.687.

[Meyer_2012-11] Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. June 2012, 149 (7): 1635–46. PMC 3383396 . PMID 22608085. doi:10.1016/j.cell.2012.05.003.

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